Chapters and reviews


Hynes R.O. (2014). Stretching the boundaries of extracellular matrix research. Nat Rev Mol Cell Biol. 2014 Dec;15(12):761-3.

Hynes, R.O. (2012). The Evolution of Metazoan Extracellular Matrix. J.Cell Biol. 196: 671-679.

Naba, A., Hoersch, S. and Hynes, R.O. (2012c). Towards Definition of an ECM Parts List: an Advance on GO Categories. Matrix Biology. 31(7/8): 371-372

Labelle, M. and Hynes, R.O. (2012). The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov. 2(12):1091-1099. doi: 10.1158/2159-8290.CD-12-0329.

Hynes, R.O. and Naba, A. (2012). Overview of the Matrisome – an inventory of extracellular matrix constituents and functions. In Extracellular Matrix Biology (eds. RO Hynes and KM Yamada). Cold Spring Harbor Perspectives in Biology. doi: 10.1101/cshperspect.a004903.

Bergmeier W. and Hynes, R.O. (2012). ECM proteins in hemostasis and thrombosis. In Extracellular Matrix Biology (eds. RO Hynes and KM Yamada). Cold Spring Harbor Perspectives in Biology. doi: 10.1101/cshperspect.a005132.

Hynes, R.O. (2011). Metastatic cells will take any help they can get. Cancer Cell 20: 689-690.

Hynes, R.O. (2009) The Extracellular Matrix: not just pretty fibrils. Science 326: 1216-1219.

Astrof, S. & Hynes, R.O. (2009). Fibronectins in Vascular Morphogenesis. Angiogenesis 12:165-75.

Hynes, R.O. (2007). Cell-matrix adhesion in vascular development. J. Thromb. Haemostasis. 5(Suppl.1) 32-40.

Xu, L. and Hynes, R.O. (2007). GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle. 6:160-165.

Wong, S.Y. and Hynes, R.O. (2006). Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide? Cell Cycle 5: 812-817.

Whittaker, C.A., Bergeron, K.F., Whittle, J., Brandhorst, B.P., Burke, R.D. and Hynes R. O. (2006). The echinoderm adhesome. Dev. Biol. 300: 252-266.

Hynes, R.O. (2004). The emergence of integrins: a personal and historical perspective. Matrix Biology 23: 331-338.

Hynes, R.O. (2003). Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants—or both? Cell 113: 821-823.

Hynes, R.O. (2002). Integrins: bi-directional, allosteric, signaling machines. Cell: 110:673-687 (almost 5,000 citations).

Hynes, R.O. (2002). A reevaluation of integrins as regulators of angiogenesis. Nature Medicine 8: 918-921.

Hynes, R.O., Lively, J.C., McCarty, J.H., Taverna, D., Francis, S.E., Hodivala-Dilke, K. and Xiao, Q. (2002). Diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harbor Symp. Quant. Biol. 67: 143-153.

Hynes, R.O. and Zhao, Q. (2000). The evolution of cell adhesion. J.Cell Biol. 150: F89-F95.

Hynes, R.O. (1999). Cell adhesion: old and new questions. Trends Millenium Issue. M33-37.

Hynes, R.O. and Bader, B.L. (1997). Targeted mutations in integrins and their ligands: their implications for vascular biology. Thromb. and Haem. 78:83-87.

Hynes, R.O. (1996) Targeted mutations in cell adhesion genes: what have we learned from them? Devel. Biol. 180: 402-412.

Hynes, R.O. and Wagner, D.D. (1996) Genetic manipulation of vascular adhesion molecules in mice. J.Clin. Invest. 98: 2193-2195

Hynes, R.O. (1994). The impact of molecular biology on models for cell adhesion. Bioessays 16:663-669.

Gotwals, P. Paine-Saunders, S., Stark, K., and Hynes, R. O. (1994). Drosophila integrins and their ligands. Curr. Opin. in Cell Biol. 6:734-739.

Hynes, R.O. and Lander, A.D. (1992). Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell 68:303-322.

Hynes, R.O. (1992). Integrins: versatility, modulation and signalling in cell adhesion. Cell 69:11-25. (almost 10,000 citations)

Hynes, R.O. (1992) Specificity of cell adhesion in development: the cadherin superfamily. Curr. Opin. Genetics and Devel. 2:621-624.

Hynes, R.O. (1991). The complexity of platelet adhesion to extracellular matrices. Thrombosis and Haemostasis. 66:40-43.

Hynes, R.O., DeSimone, D.W., Lawler, J.J., Marcantonio, E.E., Norton, P.A., Odermatt, E., Patel, R.S., Paul, J.I., Schwarzbauer, J.E., Stepp, M.A. and Tamkun, J.W. (1990). Nectins and Integrins: versatility in cell adhesion. In "Morphoregulatory Molecules", Edelman, G.M., Cunningham, B.A. and Thiery, J.-P., eds. John Wiley and Sons, NY. pp. 173-179

Hynes, R.O. (1986). Fibronectins. Scientific American, 254:42-51.

Hynes, R.O.(1987). Integrins: a family of cell surface receptors. Cell, 48:549-554 4000 citations

Hynes, R.O. (1987). Fibronectins: a family of complex and versatile adhesive glycoproteins derived from a single gene. "The Harvey Lectures", 81:133-152.

Lawler, J. and Hynes, R.O. (1987). Structural Organization of the Thrombospondin Molecule. in Seminars in Thrombosis and Hemostasis. 13:245-253. (Thieme Medical Publishers, NY).

Hynes, R.O. (1986). The interactions of fibronectin with platelets. in "Biology & Pathology of Platelet - Vessel Wall Interactions" (G. Jolles, Y. Legrand & A.T. Nurden, eds.). Academic Press Inc., London. pp. 75-91.

Hynes, R.O. (1985). Molecular Biology of Fibronectin. Ann. Rev. Cell Biol. 1:67-90.

Hynes, R.O. & Yamada, K.M. (1982). Fibronectins: multifunctional modular glycoproteins. J. Cell Biol. 95:369-377.

Hynes, R.O., Destree, A.T. and Wagner, D.D. (1982). Relationships between fibronectin, actin and cell-substratum adhesion, In, "Organization of the Cytoplasm," Cold Spring Harbor Symp. Quant. Biol. 46:659-670.

Hynes, R.O. (1981). Relationships between fibronectin and the cytoskeleton, In, "Cytoskeletal Elements and Plasma Membrane Organization" Cell Surface Reviews 7:97-139, eds. G. Poste and G.L. Nicolson, Elsevier-Biomed. Press.

Hynes, R.O. (1981). Fibronectin and its relation to cellular structure and behavior. In, "The Cell Biology of the Extracellular Matrix", ed. E.D. Hay, Plenum Press, pp. 295-333.

Hynes, R.O., Ali, I.U., Destree, A.T., Mautner, V.M., Perkins, M.E. Senger, D.R., Wagner, D.D. and Smith, K. (1978). A large glycoprotein lost from the surfaces of transformed cells. Ann. N.Y. Acad. Sci. 312:317-342.

Hynes, R.O., Destree, A.T. and Mautner, V.M. (1976). Spatial organization at the cell surface, in "Membranes and Neoplasia: New Approaches and Strategies", pp. 189-201. (V.T. Marchesi, ed.) Alan R. Liss, Inc., New York.

Hynes, R.O. (1976). Surface labelling techniques for eukaryotic cells, in "New Techniques in Biophysics and Cell Biology", 3:147-212, (R. Pain and B.J. Smith, eds.) Wiley Intl.

Hynes, R.O. (1976). Cell surface proteins and malignant transformation. Biochim. Biophys. Acta 458:73-107.

Hynes, R.O. (1974). Role of surface alterations in cell transformation: the importance of proteases and surface proteins. Cell 1:147-158.